Rastreamento de Streptococcus do Grupo B em gestantes: revisão integrativa
DOI:
https://doi.org/10.59464/2359-4632.2024.3326Palavras-chave:
Infecção Estreptocócica do Grupo B, Gestantes, RastreamentoResumo
Objetivo: identificar os melhores métodos para rastreio pré-natal para a prevenção de infecção perinatal por Streptococcus do Grupo B em gestantes. Métodos: revisão integrativa, desenvolvida nas bases de dados LILACS, PubMed e CINAHL, e nas bibliotecas virtuais SciELO e BVS, através do cruzamento das palavras “Streptococcus do Grupo B”, “Gestantes” e “Rastreamento”. A busca foi feita em março de 2024, considerando apenas a captura de artigos científicos publicados nos últimos 10 anos, com dados primários, em inglês, português e/ou espanhol, disponíveis na íntegra. A busca foi realizada com dois pesquisadores independentes, e a apresentação dos dados considerou o título do artigo, nome do periódico, autores, ano de publicação, país, tipo de estudo, objetivo, amostra, resultados e nível de evidência. Resultados: Dos 535 trabalhos identificados, apenas 14 artigos compuseram a amostra, focando em métodos diagnósticos moleculares e sua eficácia, custo, e facilidade de uso para triagem de estreptococos do grupo b. Os resultados sugerem que PCR em tempo real e outros métodos moleculares rápidos são superiores ao padrão-ouro de cultura bacteriana em termos de rapidez e precisão. Conclusão: a integração dos métodos diagnósticos avançados pode aprimorar significativamente as estratégias de prevenção da transmissão vertical da bactéria. Características socioculturais e fatores de risco das populações rastreadas devem ser consideradas para um manejo e tratamento mais específicos.
Referências
Liu Y, Liu J. Group B Streptococcus: Virulence Factors and Pathogenic Mechanism. Microorganisms. 2022 Dec;10(12):2483. doi: 10.3390/microorganisms10122483.
Gonçalves BP, Procter SR, Paul P, Chandna J, Lewin A, Seedat F, et al. Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden. Lancet Glob Health. 2022 Jun;10(6):e807-e819. doi: 10.1016/S2214-109X(22)00093-6.
Russel NJ, Seale AC, O'Driscoll M, et al. Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses. Clin Infect Dis. 2020;71(10):2020–2031.
Martins ER, Pedroso RB, Pellegrini BZ, et al. Group B Streptococcus carriage, serotype distribution and antibiotic susceptibilities in pregnant women at the time of delivery in a regional hospital in São Paulo, Brazil. Braz J Microbiol. 2018;49(3):661–668.
Melo SC, Lima EO, Guerra ACL, et al. Factors associated with group B streptococcal colonization and potential for future maternal immunization in a Brazilian maternity hospital. Rev Inst Med Trop Sao Paulo. 2019;61:e64.
Yuan XY, Liu HZ, Liu JF, Sun Y, Song Y. Pathogenic mechanism, detection methods and clinical significance of group B Streptococcus. Future Microbiol. 2021 Jun;16:671-685. doi: 10.2217/fmb-2020-0189.
Ohlsson A, Shah VS. Antibiotic prophylaxis for preventing Group B streptococcal infection in newborns. Cochrane Database Syst Rev. 2014 Jun 23;(6):CD003066. doi: 10.1002/14651858.CD003066.pub4.
Colbourn T. Prenatal Screening and Prophylaxis for Neonatal Group B Streptococcal Infection: A Review of National Guidelines. Pediatrics. 2015;135(2):e520–e532. https://doi.org/10.1542/peds.2014-1658
Seale AC, Bianchi-Jassir F. Estimates of the Burden of Group B Streptococcal Disease Worldwide for Pregnant Women, Stillbirths, and Children. Clin Infect Dis. 2017;65(suppl_2):S200–S219. https://doi.org/10.1093/cid/cix664
Ferreira MB, de-Paris F, Paiva RM, Nunes LS. Assessment of conventional PCR and real-time PCR compared to the gold standard method for screening Streptococcus agalactiae in pregnant women. Braz J Infect Dis. 2018 Nov-Dec;22(6):449-454. doi: 10.1016/j.bjid.2018.09.005.
Liu M, Wang H, Chu C, Min F, Sun L, Zhang T, Meng Q. Establishment and application of a rapid molecular diagnostic platform for the isothermal visual amplification of group B Streptococcus based on recombinase polymerase. Front Cell Infect Microbiol. 2024 Feb 23;14:1281827. doi: 10.3389/fcimb.2024.1281827.
Wang F, Yi L, Ming F, Dong R, Wang F, Chen R, Hu X, Chen X, Sun B, Tang Y, Zhu Y, Wu L. Evaluation of the Xpert Xpress GBS test for rapid detection of group B Streptococcus in pregnant women. Microbiol Spectr. 2024;12:e02206-23. https://doi.org/10.1128/spectrum.02206-23
Lemaire C, Cheminet M, Duployez C, Artus M, Ballaa Y, Devos L, Plainvert C, Poyart C, Le Gall F, Tazi A, Lanotte P. A LAMP-based assay for the molecular detection of group B Streptococcus. Eur J Clin Microbiol Infect Dis. 2023 Oct;42(10):1245-1250. doi: 10.1007/s10096-023-04656-z.
Costa SC, Machado AP, Teixeira C, Cerqueira L, Rodrigues T, Ribeiro M, Moucho M. Group B Streptococcus rectovaginal colonization screening on term pregnancies: culture or polymerase chain reaction? J Matern Fetal Neonatal Med. 2023 Dec;36(2):2262078. doi: 10.1080/14767058.2023.2262078.
Choera T, Jung-Hynes B, Chen DJ. Comparative study of Revogene GBS LB assay and GeneXpert GBS LB assay for the detection of group B Streptococcus in prenatal screening samples. BMC Infect Dis. 2020 Jan 14;20(1):38. doi: 10.1186/s12879-019-4756-y.
Zanini da Rocha J, Feltraco J, Radin V, Vitola Gonçalves C, Almeida da Silva PE, Von Groll A. Streptococcus agalactiae colonization and screening approach in high-risk pregnant women in southern Brazil. J Infect Dev Ctries. 2020 Apr 30;14(4):332-340. doi: 10.3855/jidc.12025.
Carrillo-Ávila JA, Gutiérrez-Fernández J, González-Espín AI, García-Triviño E, Giménez-Lirola LG. Comparison of qPCR and culture methods for group B Streptococcus colonization detection in pregnant women: evaluation of a new qPCR assay. BMC Infect Dis. 2018 Jul 5;18(1):305. doi: 10.1186/s12879-018-3208-4.
Tittel-Elmer M, de Tejada BM, Renzi G, Schrenzel J. Performance of the HiberGene Group B Streptococcus kit, a loop-mediated isothermal amplification-based assay for GBS screening during pregnancy. Eur J Clin Microbiol Infect Dis. 2023 Feb;42(2):217-219. doi: 10.1007/s10096-022-04534-0.
HogenEsch E, De Mucio B, Haddad LB, Vilajeliu A, Ropero AM, Yildirim I, Omer SB. Differences in maternal group B Streptococcus screening rates in Latin American countries. Vaccine. 2021 Jul 30;39 Suppl 2:B3-B11. doi: 10.1016/j.vaccine.2020.10.082.
Furfaro LL, Chang BJ, Payne MS. Detection of group B Streptococcus during antenatal screening in Western Australia: a comparison of culture and molecular methods. J Appl Microbiol. 2019 Aug;127(2):598-604. doi: 10.1111/jam.14331.
Tanaka K, Iwashita M, Matsushima M, Wachi Y, Izawa T, Sakai K, Kobayashi Y. Intrapartum group B Streptococcus screening using real-time polymerase chain reaction in Japanese population. J Matern Fetal Neonatal Med. 2016;29(1):130-4. doi: 10.3109/14767058.2014.989496.
Seto MTY, Ko JKY, Cheung KW, To KKW, Hui PW, Lao TT, Lee CP. The Accuracy of Self-Screening of Group B Streptococcus in Pregnant Women-A Randomized Crossover Study. J Obstet Gynaecol Can. 2019 Jun;41(6):792-797. doi: 10.1016/j.jogc.2018.08.003.
Radoń-Pokracka M, Piasecki M, Lachowska A, Baczkowski S, Spaczyńska J, Górecka M, Nowak M, Huras H. Assessment of the implementation of the infectious diseases screening programmes among pregnant women in the Lesser Poland region and comparison with similar programmes conducted in other European Union countries. Ginekol Pol. 2017;88(3):151-155. doi: 10.5603/GP.a2017.0029.
Pinto AM, Pereira TA, Alves V, Araújo A, Lage OM. Incidence and serotype characterisation of Streptococcus agalactiae in a Portuguese hospital. J Clin Pathol. 2018 Jun;71(6):508-513. doi: 10.1136/jclinpath-2017-204646.
Ko JK, Yung SS, Seto MT, Lee CP. A questionnaire study on the acceptability of self-sampling versus screening by cliniciansfor Group B Streptococcus. J Chin Med Assoc. 2016 Feb;79(2):83-7. doi: 10.1016/j.jcma.2015.08.005.
Molnar P, Biringer A, McGeer A, McIsaac W. Can pregnant women obtain their own specimens for group B streptococcus? A comparison of maternal versus physician screening. Fam Pract. 1997 Oct;14(5):403-6. doi: 10.1093/fampra/14.5.403.
Price D, Shaw E, Howard M, Zazulak J, Waters H, Kaczorowski J. Self-sampling for group B streptococcus in women 35 to 37 weeks pregnant is accurate and acceptable: a randomized cross-over trial. J Obstet Gynaecol Can. 2006 Dec;28(12):1083-1088. doi: 10.1016/S1701-2163(16)32337-4.
Hayes K, O'Halloran F, Cotter L. A review of antibiotic resistance in Group B Streptococcus: the story so far. Crit Rev Microbiol. 2020 May;46(3):253-269. doi: 10.1080/1040841X.2020.1758626.
Seki T, Kimura K, Reid ME, Miyazaki A, Banno H, Jin W, et al. High isolation rate of MDR group B streptococci with reduced penicillin susceptibility in Japan. J Antimicrob Chemother. 2015 Oct;70(10):2725–2728.
Martín V, Cárdenas N, Ocaña S, Marín M, Arroyo R, Beltrán D, et al. Rectal and vaginal eradication of Streptococcus agalactiae in pregnant women by using Lactobacillus salivarius CECT 9145, a target specific probiotic strain. Nutrients. 2019 Apr;11(4):810.
Furfaro L, Chang B, Payne M. Applications for bacteriophage therapy during pregnancy and the perinatal period. Front Microbiol. 2018;8:2660.
Cheesman M, Ilanko A, Blonk B, Cock I. Developing new antimicrobial therapies: are synergistic combinations of plant extracts/compounds with conventional antibiotics the solution? Pharmacogn Rev. 2017;11(22):57–72.
Tyers M, Wright G. Drug combinations: a strategy to extend the life of antibiotics in the 21st century. Nat Rev Microbiol. 2019 Mar;17(3):141–155.
Slotved HC, Hoffmann S. The Epidemiology of Invasive Group B Streptococcus in Denmark From 2005 to 2018. Front Public Health. 2020 Mar 10;8:40. doi: 10.3389/fpubh.2020.00040.
do Nascimento CS, Dos Santos NFB, Ferreira RCC, Taddei CR. Streptococcus agalactiae in pregnant women in Brazil: prevalence, serotypes, and antibiotic resistance. Braz J Microbiol. 2019 Oct;50(4):943-952. doi: 10.1007/s42770-019-00129-8.
Berner R. Group B streptococcus vaccines: one step further. Lancet Infect Dis. 2021 Feb;21(2):158-160. doi: 10.1016/S1473-3099(20)30451-5.
Madhi SA, Anderson AS, Absalon J, Radley D, Simon R, Jongihlati B, et al. Potential for Maternally Administered Vaccine for Infant Group B Streptococcus. N Engl J Med. 2023 Jul 20;389(3):215-227. doi: 10.1056/NEJMoa2116045.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2024 Revista Científica Integrada

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.











